Although we lack sufficient evidence to justify supplementing with vitamin D in the prevention and / or treatment of COVID-19 infection, to date it is becoming increasingly feasible that this hypothesis is valid. Two general basic mechanisms should be considered. One would be the anti-infective and immunomodulatory action that it exerts by improving intercellular barriers by stimulating innate immunity, as well as by modulating adaptive immunity. Also, vitamin D reduces the production of inflammatory cytokines such as IL-2 and interferon gamma (INF-γ).
More recently, multiple pleiotropic effects have been demonstrated on the actions of vitamin D at the anti-inflammatory and immunomodulatory level. This explains positive results in studies with influenza, coronavirus, and other respiratory infections. An inverse relationship between serum vitamin D levels and the prevalence of respiratory infectious disease has been described. Of interest, another mechanistic approach responds to considering the inhibition of the renin-angiotensin-aldosterone system, which is exacerbated in COVID-19 infection because the virus binds to the ECA2 enzyme, leaving more angiotensin II available to cause damage.
Vitamin D inhibits RAAS mediators – present in all cells of the body – and by inhibiting ACE activity and increasing ACE2, it decreases angiotensin II levels. We present studies with proposals for recommended doses of vitamin D, and although no single guide has been established, the possible benefits are promising. With our orange multivitamin, you can cover the dose of vitamin D necessary to prevent yourself from Coronavirus, you can buy here.